OPTIMIZATION OF DEEP LEARNING-BASED MODEL FOR IDENTIFICATION OF CREDIT CARD FRAUDS


Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

Monoclonal antibodies (mAbs) deliver great benefits to patients with chronic and/or severe diseases thanks to their strong specificity to the therapeutic target.As a result of this specificity, non-human primates (NHP) are often the only preclinical species in which therapeutic antibodies cross-react with the target.Here, we highlight the value and

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Development and formation conditions of karst collapse induced by tunnel engineering in the Gele Mountain area

In recent years, Digital Portion Scales intensive tunnel construction has induced a large number of karst collapses in the Gele Mountain area.However, the distribution, scale, cause and evolution of karst collapses have not been systematically summarized.By means of data collation, drilling data analysis, monitoring data interpretation and other wo

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Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Summary: Omicron, as the emerging variant with enhanced vaccine tolerance, has sharply disrupted most therapeutic antibodies.Severe acute respiratory syndrome coronavirus Digital Portion Scales 2 (SARS-CoV-2) belongs to the subgenus Sarbecovirus, members of which share high sequence similarity.Herein, we report one sarbecovirus antibody, 5817, whic

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